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Gastrointestinal Side Effects Common side effects include nausea, vomiting, and diarrhea, which can sometimes lead to dehydration or electrolyte imbalances
Use raw heart-rate change rather than placebo-subtracted when assessing drug-attributable load: the placebo arm shows real cardiovascular adaptation from weight loss and lifestyle counseling, so subtraction over-corrects
In the SURMOUNT-2 trial, tirzepatide 15mg weekly produced 22.2% body weight reduction over 72 weeks, while comparable semaglutide trials (STEP-4) showed 17.4% reduction at the maximum dose
Semaglutide may not be suitable for you if: Have less than 10lbs to lose You have allergies to any of the ingredients in the medication You are on medications that may interact with semaglutide You are pregnant, breastfeeding or planning or actively trying to conceive Some medical conditions and family history require consultation with a doctor prior to starting this medication Our Naturopathic Doctors will consult with you to determine if semaglutide is a safe and appropriate option for you, or if alternative approaches may be more suitable
Fibers such as XOSs or AXOSs may be effective at 12 g/day, while inulin and FOSs often require 520 g/day, creating meaningful differences in formulation flexibility, serving size, and unit economics
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