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Additionally, the expression of oxidatively modified proteins and lipid peroxidation-derived products, such as 13-hydroperoxy-9Z,11E-octadecadienoic acid and 4-hydroxy-2-nonenal, was significantly increased in the brains of the T21 mouse models

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No randomized trials No controlled studies No validated imaging or outcome measures Only one very small, biased case series 2

Both amounts remain within established safety thresholds for most healthy adults.51 52 Still, its worth keeping in mind especially for people who already supplement folate or vitamin D separately that combination products offer less flexibility when adjusting servings

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