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Currently, research on GLP-1 agonists during pregnancy is limited, and most guidelines recommend against their use while pregnant due to potential unknown effects on fetal development

Oral semaglutide (brand name Rybelsus) uses a specific absorption enhancer to survive the digestive tract and reach the bloodstream, but its oral bioavailability is very low compared with injectables

History: In the early 2000s, GLP-1-based drugs (exenatide and liraglutide) were developed for the treatment of type 2 diabetes

Maneli MH, Wiesner L, Tinguely C, et al

D Metformin in T1D: modest insulin-dose reduction, commonly cited around 5% in practice summaries

It is typically irregular and will grow slowly, often starting its expansion in a radial pattern