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The cardiovascular safety and efficacy of tirzepatide in adults with T2D has been assessed in a large phase 3 clinical trial (SURPASS-CVOT) (Table 1) [88]
Based on Phase 2 clinical trial protocols, retatrutide was administered as a once-weekly subcutaneous injection , similar in delivery method to other incretin-based therapies such as semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound)
ASAT decreased by 13-43% depending on dose and treatment length
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The cause of this change is unknown although it is probably artifactual and may relate to the effect of a local anesthetic
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