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The mechanism of metformin has been studied endlessly, but the mechanism has not yet been fully clarified

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(2017) The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility, Nat

Following these data, deletion of endogenous Mecp2 with a specific small hairpin RNA interference reduced spine density after 96 h of expression and decreased the number of mature-shaped dendritic spines [374]

Simultaneously, decarboxylated S-adenosylmethionine (dcSAM), derived from Met metabolism, serves as the source of aminopropyl groups for the synthesis of spermidine and spermine (Wallace et al., 2003)

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