Since tirzepatide has been shown to induce medullary thyroid carcinoma in both in vivo rat models and in vitro studies, it is not recommended for use in patients with a history of medullary thyroid carcinoma or those with multiple endocrine neoplasia type 2 syndrome
2,3 In REDEFINE 1, adverse events were mainly gastrointestinal, (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)
However, excessive intake or poor hydration can occasionally lead to mild side effects
If you are using a GLP-1 medication, you may notice changes in appetite and how much you eat
Although we are discontinuing the L-Carnitine formulation, we will continue to offer tirzepatide in combination with Vitamin B12 from our other trusted pharmacy
Mansour MR, Hannawa OM, Yaldo MM, Nageeb EM, Chaiyasate K