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The critical role of BCAT4 in controlling metabolic flux is unequivocally demonstrated by genetic evidence: bcat4 knockout mutants in Arabidopsis thaliana exhibit a dramatic 5060% reduction in aliphatic glucosinolates and a concurrent 5- to 12-fold accumulation of free methionine (14)

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Importantly, the animal models treated with the nanoparticles did not show any signs for pain, stress, or discomfort, and did not lose any weight (Fig

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7f) and collagen deposition (vehicle vs