Mice not pretreated with buthionine sulfoximine, but administered GSH, experienced an increase in plasma GSH, but not tissue GSH
Benefits of Intranasally Administered DSIP There are a number of potential benefits of DSIP intranasal delivery: Intranasally administered DSIP can be delivered directly to the brain, bypassing the BBB
Based on these mechanisms, emerging interventional strategies have been proposed to curb intercellular ferroptotic spread, including: blocking exosome-mediated signal transmission, inhibiting STING pathway activation, and enhancing astrocytic phagocytic and clearance functions
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It supports mitochondrial function within neurons, helps recycle acetyl-CoA (which boosts production of the neurotransmitter acetylcholine), supports membrane and phospholipid production, and acts as an energy source for neural cells