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All optimized cut-off value were selected based on the Youden Index (YI) and were provided in Supplementary section

It binds with high affinity to HGF inducing dimerization and Met phosphorylation in the presence of subthreshold levels of HGF [Figure 2] [74]

Factors affecting the degradation and drug-release mechanism of poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)]

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By inhibiting this interaction, FOXO4-DRI allows reactivation of the apoptotic pathway in non-proliferative senescent cells, leading to their selective elimination without damaging healthy tissue

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