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It is strong preclinical evidence, not clinical proof, and it is often mis-cited as being about GHK-Cu specifically
The practical advantages of topical: easy to apply, local delivery, lower systemic exposure, and you don't need a needle
Nat Rev Drug Discov 15:379380 Sun D, Gao W, Hu H, Zhou S (2022) Why 90% of clinical drug development fails and how to improve it
A known allergy to Semaglutide or GLP-1 receptor agonists
However, as with any supplement, potential side effects and safety considerations exist, particularly for individuals with pre-existing health conditions
For deeper reading: Jastreboff AM, Kaplan LM, Frias JP, et al
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