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These assets target a fast-expanding market driven by rising obesity and type 2 diabetes rates
In a rat model of migraine, trigeminal neurons have been shown to have abnormal mitochondrial biogenesis capacity represented by the decreased mitochondrial DNA number of copies as well as the altered mRNA levels of peroxisome proliferator-activated receptor-gamma coactivator-1a (31), an essential regulatory factor in mitochondrial biogenesis (32)
PloS one , 16 (3), e0247307
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Other clinical applications of methylene blue include improvement of hypotension associated with various clinical states, an antiseptic in urinary tract infections, treatment of hypoxia and hyperdynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome, and treatment of ifofosamide induced neurotoxicity
It has gained attention as a low-calorie sweetener that has minimal effects on blood glucose levels in most studies, making it of potential interest in diabetes management and weight control strategies
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