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Elevated oxidative stress drives lipid peroxidation, generating reactive derivatives that further compromise cellular function, while disturbed lipid metabolism simultaneously enhances ROS production (Supplementary Table S4)

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For tumour xenograft models, 1 10 6 HCC-1806 cells or 5 10 6 PC3 cells were injected into the right fourth mammary fat pad or hind flank of athymic nude NU/J mice (The Jackson Laboratory, 002019) in 100 l sterile PBS or a 1:1 mixture of cell suspension in PBS and Matrigel (Corning, 356237) using a 29-gauge 1 ml insulin syringe

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Note: IV glutathione should only be administered under medical supervision because of the potential for adverse reactions and the need for clinical monitoring