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In a rodent model for obesity, tirzepatide administration induced a loss of body weight, by mechanisms of reducing food intake and by increasing energy expenditure (65)

(PubMed) Age-Related Eye Disease Study Research Group

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This line derives from a cross between the Trkb- floxed ( Trkb lx ) line, as previously described 65 , and the BAC -Penk - cre tg/+ strain, carrying Cre recombinase under the control of the pre-pro-enkephalin promoter as previously described 13

A 1.5 percentage point absolute reduction and a 20 percent relative reduction

It frames them as something to discuss with a provider, either as a clinical option or as a bridge during authorization delays