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10.1016/j.cell.2013.12.010 59 YangY.TangB
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While much of the foundational work was in vitro and animal studies, we're seeing more sophisticated human trials emerging, especially in dermatological and cosmetic research applications
In Japan, ALS patients received B12 shots of 25,000-50,000mcg (each shot equal to 25-50 pernicious anemia shots all at once), at first daily and then twice a week
So we want their insulin sensitive
It's worth noting that crash diets or extreme calorie restriction may actually impair metabolic function, so gradual, sustainable changes are preferable
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