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And some research has raised, if not red flags, perhaps a few yellowish ones

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The first injection in port A contained the substrate for each individual respiratory chain complex (I: 5 mM pyruvate + 2.5 mM malate, II: 10 mM succinate + 1 M rotenone, III: 0.5 mM duroquinol, IV: 0.5 mM TMPD + 2 mM ascorbic acid) along with 1 mM ADP and 10 nM recombinant perfringolysin O (Agilent Technologies)

doi:10.18632/oncotarget.11168 Sakuma S, Ishimura M, Yuba Y, Itoh Y, Fujimoto Y

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This clinical situation can lead to interruption and/or modification of the drug schedule or even discontinuation, potentially affecting patient survival and clinical outcomes [80, 81]