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Unlike semaglutide, tirzepatide is a dual receptor agonist targeting both GLP1R and GIPR
However, chronic inhibition or ablation of ARC AgRP/NPY neurons or chronic activation of ARC POMC neurons fails to affect body weight in a stable manner [139,140,141,142]
Why the research doesn't support stopping and starting It's also worth noting that current clinical consensus and available evidence doesnt support using GLP-1 medications as a short-term fix - something to use to lose weight quickly, stop, and restart later if the weight comes back
No blood work
doi: 10.2174/1573402115666190415161813 142
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