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This proposed pathway has prompted interest in its potential role in glucose regulation, although such research remains in preliminary stages

Dehydroascorbate is reduced to ascorbate by dehydroascorbate reductase in the presence of GSH, yielding oxidized glutathione (GSSG)

Preclinical and clinical data suggest that FXR and PPAR dual modulators can improve insulin sensitivity, reduce hepatic steatosis, and attenuate fibrosis, which may complement the actions of GLP-1/GIP/GCG receptors agonists

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