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One is that some studies have linked GLP-1s to depression and anxiety, so I dont recommend someone who has severe postpartum depression to initiate a GLP-1, says Lofton

The mechanism of GLP-1 action in PWS involves binding to receptors in the nucleus tractus solitarius and other brainstem regions critical for feeding behavior

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they lack rigorous quality and safety standards required of licensed medicines

Its best to avoid layering these treatments unless your dermatologist specifically advises it

Gradual dose reduction rather than abrupt cessation may minimize rebound effects, though optimal discontinuation strategies require further study