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In the STEP 1 trial which studied semaglutide in adults with overweight or obesity, researchers studied body mass composition as a secondary endpoint via DXA in a subpopulation of trial enrollees randomized to treatment or placebo

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Chazelas P, Steichen C, Favreau F, Trouillas P, Hannaert P, Thuillier R, et al

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The consequences of this mutation suggests that -MSH may be a significant endogenous anorectic agonist that activates the MC4R

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