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Cagrilintide Starting Dose and Titration Unlike tirzepatide's gradual multi-step escalation, cagrilintide trials have typically employed a simpler titration approach: Typical Cagrilintide Escalation: Weeks 1-4: 0.6 mg weekly Weeks 5-8: 1.2 mg weekly Week 9 onward: 2.4 mg weekly (maintenance) This three-step approach allows for tolerance development while reaching the therapeutic dose more quickly than tirzepatide's six-step protocol

Frequency: 5 days on, 2 days off

Although some primary studies were included in multiple meta-analyses, the overall level of overlap was low, indicating a limited impact of duplicate data

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Quick Comparison Table# Mechanism of Action Comparison# Melanotan-1# Melanotan-1 (afamelanotide