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Hypoxia signaling also interacts with the PI3K-mTOR pathway and plays an important role [508]

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The vast array of chemical constituents in tobacco smoke, including nicotine, nitrosamines, aromatic hydrocarbons, vinyl chloride, and cadmium, plays a central role in these pathological processes [4]

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MPTP, which selectively damages nigrostriatal dopaminergic neurons through its metabolite MPP + , is a commonly used model for studying the pathological mechanisms of PD

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