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Exocytosis of synaptic vesicles (SV) containing neurotransmitters is initiated by Ca 2+ influx through voltage-gated Ca 2+ channels during excitation of the presynaptic bouton
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It is hypothesized that semaglutide may enter through circumventricular organs, specialized brain regions such as the area postrema that lack a traditional blood-brain barrier, or via slow, low-capacity transport mechanisms (Athauda et al., 2026)
World J Gastroenterol, 2017
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