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[6] NAD+ augmentation may counteract age-related NAD+ loss caused by overactive NAD-consuming enzymes (such as the NADase CD38), thereby supporting mitochondrial maintenance and metabolic homeostasis

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synthesized by certain bacteria Although the intestinal flora of humans is able to synthesize vitamin B 12 , humans are not able to absorb bacteria-generated vitamin B 12 since the location of synthesis (the colon) is too distal from the location of absorption (the small intestine)