Regulatory agencies require extensive clinical evidence before approval, and the absence of such data means safety and effectiveness remain uncertain
12,25 Tirzepatide, by contrast, exerts its effects through dual agonism of both GIP and GLP-1 receptors, resulting in a distinct pharmacological profile
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During the study, one patient died and another was hospitalized, but these events were not considered related to study participation
doi:10.1016/j.jcjd.2018.05.008