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It was tolerated quite well. Frias said the tolerability may have been due to the dose escalation protocol
This can occur due to the enlargement of the left ventricle (dilated cardiomyopathy), abnormal thickening of the heart muscle (hypertrophic cardiomyopathy), or stiffening of the heart muscle that prevents it from adequately expanding and filling with blood (restrictive cardiomyopathy)
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