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Liles NW, Page EE, Liles AL, Vesely SK, Raskob GE, George JN
Upregulation of caveolin-1 contributes to aggravated high-salt diet-induced endothelial dysfunction and hypertension in type 1 diabetic rats
Data Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide (0.03-, 0.07-, and 0.5-fold the MRHD of 15 mg once weekly based on AUC) during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg
126 This unsupervised analysis revealed novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort
This custom, digital smile is then used to reverse engineer a patient-specific bracket position that is precisely transferred to the patients teeth with a 3D-printed custom tray
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