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Unlike homocysteine, which responds to both B12 and folate intake, the metabolite methylmalonic acid (MMA) specifically responds to B12 intake, and for some time we viewed MMA levels as the most important measure of B12 activity

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Sikiric and colleagues have repeatedly characterized it as "stable in human gastric juice," a property attributed to its high proline content and the absence of cleavage-prone residue pairs (Sikiric et al., 2018)

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