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On the cardiovascular side, the SUSTAIN-6 trial in 2016 was one of the first to report a significant reduction in major adverse cardiovascular events with semaglutide in adults with type 2 diabetes and high cardiovascular risk (Marso et al., NEJM, 2016)

Additional Resources Press Releases Helix Launches World's Largest Clinico-Genomic Cohort of GLP-1 Agonist Treated Patients Read More Research White Paper: Semaglutide and Weight Management Read More Webinars Metabolic risk factors and BMI-associated variants influencing weight loss with Semaglutide Read More Connect with us!

Start your intake What Does GLP-1 Non-Response Actually Mean GLP-1 non-response occurs when a patient follows a consistent semaglutide protocol but loses less than 5% of their starting body weight after 12 weeks or experiences weight loss plateau before reaching therapeutic goals

Subgroup analyses were available for PIONEER 3 and 4, which generally showed consistent treatment effects by background therapy for A1C or body weight (metformin with or without SU in PIONEER 3, metformin with or without SGLT2 inhibitor in PIONEER 4)

The study included people with cirrhosis, or scarred and permanently damaged livers

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