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Inflammation and Cytokine Modulation: ERK1/2 pathway activation, reduction of inflammatory cytokines (TNF-, IL-6), AKT phosphorylation enhancement, KRAS expression modulation
Doses above ~500 mcg/day are not generally linked to added benefit in the reference literature, and none of this reflects proven human efficacy
International Units describe biological activity rather than mass, which makes them a more direct indicator of expected effect at the receptor
They can also recommend treatments for specific side effects where necessary
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They also may justify additional diagnosis codes for peripheral neuropathy
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