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Processes were undocumented, informal, inherited from structures that no longer exist
But it should be noted that at meantime of brain protection, BBB also excludes more than 98% of small-molecule drugs and all macromolecular therapeutics from access to the brain
Importantly, no significant adverse effects were observed, and patients did not develop tolerance or rebound insomnia upon discontinuation
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Why pair them The pathways overlap on satiety and gastric emptying but engage different receptor families
doi:10.1038/nchembio.1204
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