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B12 from food and supplements has to pass through a fairly involved process in the stomach and gut before your body can use it, and that process becomes less efficient with age, with certain medications, and with diets that include little or no animal protein

The metabolic basis for developmental disorders due to defective folate transport

doi: 10.1007/S12522-011-0105-6 137

Thomson 1990

Promoting better cardiovascular health and anti-aging Easing anxiety and promoting relaxation and reducing pain IV therapy formulas work because these very same vitamins, minerals and cofactors are the building blocks of our cells, driving energy production and optimizing organ function

B12 is crucial for converting food into usable energy, so restoring optimal levels can significantly reduce tiredness and lethargy