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The FDA looks to see whether the data support use in the targeted populations
This is partly because the body's weight set point defends against the lower weight, and partly because GLP-1 receptors in the brain that were being continuously stimulated are no longer activated
These include reinforcement of intestinal epithelial barrier integroty, the modulation of gut microbiota composition and metabolic profiles, and improvement of antioxidant capacity, all of which contribute to mucosal repair and sustained disease stability
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