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5-Amino-1MQ for Diabetes and Metabolic Disorders NNMT is a potential biomarker for reduced insulin sensitivity, since higher activity of this enzyme has been linked to insulin resistance and type 2 diabetes [9]
This determination was based on chronic toxicity studies, genotoxicity studies, and human clinical trial safety data
PubMed, Edenberg, Howard J
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Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy
