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Despite its therapeutic efficacy, tacrolimus has a narrow therapeutic window (520 ng/mL whole blood 1012 h post-dose) and frequently displays episodes of toxicity, such as nephrotoxicity, neurotoxicity, and glucose intolerance (Chow et al., 1997)

Regulation of paracellular permeability by Na-glucose cotransport

For some patients, one medication may be more appropriate than the other depending on their health history, treatment goals, and how their body responds to therapy

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O'Mahoney LL, Matu J, Price OJ, et al

Disruptive symptoms can stall out attempts to exercise Look, we know that IBS symptoms can be embarrassing and seem like they always show up at the most inopportune times