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Long-term treatment must be considered in addition to short-term medicines, taking into account the potential consequences of the artificial tears, anti-inflammatory eye drops, and punctal plugs are examples of conventional treatments for dry eye disease that can be successful, but long-term use can be costly and may result in adverse effects that limit patient adherence [38, 39]

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These ligands can be stably attached to the surface of exosomes through covalent bonds to enhance their targeting ability

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J Endocrinol (2012) 215(2):189206