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Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione
90 CohenT
The subsequent release of cytokines, such as interleukin-1 beta (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-), and of reactive oxygen species (ROS) from microglia generates a harmful microenvironment in which reactive astrocytes acquire a neurotoxic A1 phenotype [8, 13,14,15,16,17,18]
Currently, 54 published research studies appear listed in citation form
Campistol J
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