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Its longer half-life allows for less frequent dosing, typically twice weekly
Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver
That said, these studies are tiny
Q: 5 What are the known safety concerns
Clinical Indications for Higher IV Dosages For very severe cases, like serious neurological problems, higher doses of IV vitamin B12 might be needed
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