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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations HCC: hepatocellular carcinoma CAH: chronic active hepatitis STAT: signal transducer and activator of transcription Grb-2: growth factor receptor-bound protein 2 ERK: extracellular signal-regulated kinase NF-B: nuclear factor B TNF: tumor necrosis factor MAPK: mitogen activated protein kinase JNK: c- jun N-terminal kinase NF-AT: nuclear factor of activated T cells References Brchot C (1997) Hepatitis C virus 1b, cirrhosis, and hepatocellular carcinoma

Collectively, these translational challenges provide a rationale for investigating dual PDE1B/PDE10A inhibition, which has the potential to achieve broader modulation of dopaminergic circuits and to improve symptomatic outcomes at lower, potentially safer doses compared with single-target approaches