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Likewise, GLP-1s have shown other wide-reaching benefits, such as improving cholesterol and blood pressure levels, and reducing the risk of stroke

As weight decreases and the body adapts, the overall effect on weight can become less pronounced, even if appetite remains controlled

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134 CAFs, TAMs, and extracellular matrix components modulate drug accessibility, alter immune cell trafficking, and preserve CSC niches

Research has extensively explored the effects of endogenous and exogenous GLP-1 on brain activity related to homeostasis and reward systems, particularly in the context of obesity and type 2 diabetes mellitus (T2DM)

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