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For individuals who do not respond to GLP-1, this tailored, phenotype-driven methodology within a stepped-care framework guarantees more precise and efficacious interventions, affirming the early use of medication as a scientifically substantiated and personalised strategy rather than a mere pragmatic option

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Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21 WAF1/Cip1 and p27 Kip1 and with induction of differentiation in HL60 Cells

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Arch Intern Med 1999;159:1143-4

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