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DPP-4 Inhibitors As mentioned above, DPP-4 inhibitors are now an established and successful class of oral anti-hyperglycaemic agents, and are firmly embedded in guidelines for treating T2DM patients without atherosclerotic cardiovascular (CV) disease (116, 117)
What if I get severe nausea
Semaglutide works by mimicking a natural hormone called GLP-1 (glucagon-like peptide-1), which helps regulate both digestion and metabolic processes, contributing to improved blood sugar within a healthy range, appetite control, and a balanced digestive process
Side effects are broadly similar, with tirzepatide more often linked to nausea and vomiting, and semaglutide more to constipation and reflux
That said, if medication nonadherence was a major factor for the blunted glycemic outcomes, the question remains why GLP-1 analog therapy did mediate significant weight loss, especially in women and SSRI users
Like semaglutide, higher therapeutic doses have not been specifically studied in nursing mothers
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