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First, it boosts insulin secretion from the pancreas

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

And thats why GLP-1s are very confusing, but if you want a patient to be successful on them, you want to make sure youve got the lifestyle, you got the right expectations, you know what the entry point is, what the duration is, and more importantly, what happens when they hit a weight and quote unquote, what is the endpoint of GLP-1s

But staying hydrated is non-negotiable for your energy levels, preventing constipation, and tolerating the medication (especially if you're battling nausea, vomiting, or diarrhea)

Because common GI side effects like nausea, constipation, and fatigue are often related to dose size, starting with a lower dose may help reduce the chances of feeling uncomfortable

These are the most common side effects that appear during the start of the medication or during the dose escalation period