The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure
They are incredibly effective at lowering A1C, often dropping it by 1% to 2%
Endocrine (2014) 46(3):56876
doi: 10.1038/nbt0906-1078 PubMed Abstract | CrossRef Full Text | Google Scholar Rengel, Z., Batten, G
Read full disclaimer Different Dosage Schedules for Different GLP-1s Before we dig into specific discussions, it's important to recognize that different GLP-1s have different dosages and, thus, different recommendations for adjusting those dosages
At 12mg weekly, the maximum studied dose, mean weight reduction hit 24.2% in Phase 2 and 28.7% in Phase 3 (TRIUMPH-4)