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This reaction has two consequences studied in the literature: it consumes S-adenosyl methionine, the cells principal methyl donor, and it removes nicotinamide from the salvage pathway that regenerates NAD+
Subcutaneous administration of vitamin B12 is sometimes employed, especially in patients with congenital cobalamin metabolism disorders who require high doses to maintain normal metabolic pathways
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It is vital for red blood cell production, and maintaining a healthy nervous system, and plays a key role in DNA synthesis
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