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It is commonly utilised in controlled laboratory research involving melanocortin receptors (MC1RMC5R) and associated signalling pathways

J Dermatol 40(1):6364

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However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH