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However: No large, peer-reviewed human trials exist demonstrating proven benefit

One study found people with obesity who had higher levels of glutathione lost more weight when they followed a healthy eating plan for 6 months

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It has several physiological effects, such as modification of heart rate, blood pressure, pain threshold and some lymphokine system functions

Furthermore, TXNIP shows context-dependent subcellular localization and expression changes under conditions such as high-glucose exposure, proteinuria-induced ERS, and uric acid-mediated inflammation, which in turn modulate oxidative stress, inflammation and cell fate (5153)