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The answer is that, although the high-valent metal-oxo heme cores of these intermediates are in fact very similar, the substrate-binding cavities seem to differ substantially in how much access the substrate has to the iron center
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Semaglutide and nonarteritic anterior ischaemic optic neuropathy [PMID: 39870391] Laboratory literature summary: Semaglutide and nonarteritic anterior ischaemic optic neuropathy
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Do not exceed 8 doses per month
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