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Moreover, these methods may not provide a continuous hormone release, resulting in variable therapeutic effects

Water was changed weekly

Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D et al

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During ischemia, ATP depletion and ionic imbalance induce mitochondrial depolarization, mPTP opening, and early accumulation of mitochondrial ROS (mtROS)