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Tirzepatide's dual-agonist mechanism distinguishes it from single GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

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The visibility and evidence generation that will be derived from this approach will benefit all healthcare leaders in improving overall health and reaching a more cost-effective state for GLP-1 agonists within the obesity market