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68,69 In addition to activating the cAMP/PKA pathway, activation of GLP-1R has been associated with other intracellular mechanisms such as the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which plays a crucial role in regulating key functions like cell survival, mitochondrial activity, and autophagy, or the breakdown and recycling of damaged cellular components
GLP-1 treatment helps restore biological balance, including hunger cues and insulin sensitivity, which are often disrupted in individuals with obesity
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However, we found GPX4 concentrated in dystrophic axons and colocalization of GPX4 with TH in axonal varicosities (shown by white arrowheads)
For most patients on a stable dose, the body handles this slight overlap without issue
They're normal signs of GH elevation
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